Built in 1848-49 to a design by George Gilbert Scott in the 15th century Decorated style. The east window of its chancel was designed by Ninian Comper. In 1930, C. S. Lewis, Oxford academic and author of The Chronicles of Narnia, and his brother Warnie moved, with Mrs Janie Moore and her daughter Maureen, into “The Kilns”, a house on the outskirts of Headington Quarry. Lewis attended Holy Trinity Church. He first preached there on 29 March 1942, on the subject of “Religion and pleasure”, and he is buried in the churchyard.
The Friends of Holy Trinity Church was founded in 2002 to raise funds and look after the church.